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White plastic pill bottle labeled "LGD-3033, 10 mg, Batch No.003, 05-07-2025" on a beige background, with two white capsules lying beside it
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LGD-3033 100x10mg

€80,00 EUR
Taxes included.

                                            NOT FOR HUMAN CONSUMPTION

LGD-3033 is one of the less commonly discussed SARMs. Information on its chemical structure, receptor affinity, and pharmacodynamics is still limited compared to more well-known SARMs like LGD-4033 (Ligandrol) or Ostarine (MK-2866).

1 Muscle hypertrophy & lean-mass restoration Oral LGD-3303 (1 mg kg⁻¹ day⁻¹) fully restored levator-ani weight in castrated rats and prevented catabolic loss of lean tissue within 14 days.
Journal of Pharmacology & Experimental Therapeutics; Journal of Bone & Mineral Research
2 Bone-density accrual In ovariectomised rats the SARM increased cortical and trabecular BMD/BMC at spine and femur, partly via periosteal bone formation.
Journal of Bone & Mineral Research
3 Additive synergy with bisphosphonate Combined LGD-3303 + alendronate produced equal or greater gains in bone mass/strength than either monotherapy—supporting dual-mode osteoporosis regimens.
Journal of Bone & Mineral Research
4 Tissue selectivity (minimal prostate stimulation) Even at high doses ventral-prostate weight never exceeded 50 % of intact controls, confirming strong anabolic-to-androgenic dissociation.
Journal of Pharmacology & Experimental Therapeutics
5 Oral bioavailability & convenient PK Once-daily gavage achieved stable muscle-selective exposure; tissue selectivity persisted with oral or continuous-infusion delivery.
Journal of Pharmacology & Experimental Therapeutics
6 Frailty mitigation & functional strength In osteopenic female rats LGD-3303 increased hind-limb grip strength and improved biomechanical bone parameters, indicating anti-frailty potential.
Journal of Bone & Mineral Research
7 Sexual-behaviour enhancement (neuromodulation) Doses of 3–30 mg kg⁻¹ intensified proceptive and lordosis behaviour in gonadectomised female rats—suggesting AR-mediated CNS actions without aromatisation.
Endocrinology
8 Improved body-composition & adiposity profile SARM treatment lowered fat-body-mass percentage while preserving total body weight in androgen-deficient models.
ACS Journal of Medicinal Chemistry
9 Limited off-target nuclear-receptor binding Competitive assays show little cross-reactivity with PR, ER or GR, hinting at a cleaner safety margin compared with steroidal androgens.
Journal of Bone & Mineral Research
  • Research Status:

    • Preclinical/Animal Studies: Most of the available data on LGD-3033 is derived from preliminary studies or anecdotal reports. Peer-reviewed research on its efficacy and safety profile remains scarce.
    • Human Trials: As of now, there are no widely recognized clinical trials or studies in humans that definitively establish its benefits, optimal dosage, or long-term side effects.

3. Mechanism of Action

  • Androgen Receptor Selectivity:
    LGD-3033 is designed to selectively bind to androgen receptors in muscle and bone tissues. The goal is to stimulate anabolic (muscle-building) processes without significantly affecting other tissues that are commonly impacted by anabolic steroids (such as the prostate).

  • Potential Effects:

    • Anabolic Effects: Increased protein synthesis, muscle growth, and improved strength.
    • Bone Health: Potential improvement in bone density, which is why SARMs are often researched for osteoporosis.

4. Potential Benefits

Based on its design as a SARM, LGD-3033 might offer:

  • Increased Lean Muscle Mass: Users often seek SARMs to help enhance muscle mass while reducing body fat.
  • Enhanced Strength and Performance: Potential improvements in muscle strength and recovery time.
  • Bone Density Improvement: A secondary benefit that is being explored in the context of treating bone degeneration disorders.

5. Dosage & Usage

  • Lack of Standardized Protocol:
    Due to the experimental nature of LGD-3033, there is no medically or scientifically validated dosage. Most dosing guidelines circulating online are based on anecdotal reports and user experiences rather than rigorous clinical research.

  • Cycle Recommendations:
    In anecdotal discussions within underground forums, some users report cycles ranging from 6 to 8 weeks. However, these are not clinically approved regimens and come with risks.

  • Stacking Practices:
    Some individuals may stack LGD-3033 with other SARMs or compounds. Such combinations can increase the complexity of the effects and the potential for adverse reactions.

6. Safety & Potential Side Effects

  • Side Effects:
    While SARMs are often touted for their reduced side effect profile compared to anabolic steroids, potential risks still exist:

    • Hormonal Imbalances: Disruption of the natural endocrine system, which could lead to testosterone suppression.
    • Liver Toxicity: Although generally considered lower than oral steroids, liver enzymes should be monitored.
    • Cardiovascular Issues: Potential effects on cholesterol levels and cardiovascular health.
    • Other Unknowns: Because LGD-3033 is less studied, long-term effects and risks remain largely unknown.
  • Post-Cycle Therapy (PCT):
    Anecdotal evidence suggests that some users might employ a PCT regimen after a cycle to help restore natural hormone levels. However, without clinical guidance, this practice can be risky.

7. Legal and Regulatory Status

  • Research Chemical:
    LGD-3033 is typically sold as a research chemical. It is not approved by regulatory agencies (such as the FDA or EMA) for human consumption or as a dietary supplement.

  • Legality:
    The legal status of SARMs, including LGD-3033, varies by country. In many regions, possession or sale for human use can be illegal, and products are intended strictly for laboratory research purposes.

8. Current Research and Future Directions

  • Need for Clinical Trials:
    More rigorous, controlled human studies are needed to determine the efficacy, safety, and proper dosing of LGD-3033.

  • Potential Medical Applications:
    If proven safe, SARMs like LGD-3033 could have therapeutic potential in treating muscle-wasting diseases, osteoporosis, and other conditions where muscle and bone health is compromised.