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NOT FOR HUMAN CONSUMPTION
LGD-3033 is one of the less commonly discussed SARMs. Information on its chemical structure, receptor affinity, and pharmacodynamics is still limited compared to more well-known SARMs like LGD-4033 (Ligandrol) or Ostarine (MK-2866).
1 Muscle hypertrophy & lean-mass restoration | Oral LGD-3303 (1 mg kg⁻¹ day⁻¹) fully restored levator-ani weight in castrated rats and prevented catabolic loss of lean tissue within 14 days. |
Journal of Pharmacology & Experimental Therapeutics; Journal of Bone & Mineral Research |
2 Bone-density accrual | In ovariectomised rats the SARM increased cortical and trabecular BMD/BMC at spine and femur, partly via periosteal bone formation. |
Journal of Bone & Mineral Research |
3 Additive synergy with bisphosphonate | Combined LGD-3303 + alendronate produced equal or greater gains in bone mass/strength than either monotherapy—supporting dual-mode osteoporosis regimens. |
Journal of Bone & Mineral Research |
4 Tissue selectivity (minimal prostate stimulation) | Even at high doses ventral-prostate weight never exceeded 50 % of intact controls, confirming strong anabolic-to-androgenic dissociation. |
Journal of Pharmacology & Experimental Therapeutics |
5 Oral bioavailability & convenient PK | Once-daily gavage achieved stable muscle-selective exposure; tissue selectivity persisted with oral or continuous-infusion delivery. |
Journal of Pharmacology & Experimental Therapeutics |
6 Frailty mitigation & functional strength | In osteopenic female rats LGD-3303 increased hind-limb grip strength and improved biomechanical bone parameters, indicating anti-frailty potential. |
Journal of Bone & Mineral Research |
7 Sexual-behaviour enhancement (neuromodulation) | Doses of 3–30 mg kg⁻¹ intensified proceptive and lordosis behaviour in gonadectomised female rats—suggesting AR-mediated CNS actions without aromatisation. |
Endocrinology |
8 Improved body-composition & adiposity profile | SARM treatment lowered fat-body-mass percentage while preserving total body weight in androgen-deficient models. |
ACS Journal of Medicinal Chemistry |
9 Limited off-target nuclear-receptor binding | Competitive assays show little cross-reactivity with PR, ER or GR, hinting at a cleaner safety margin compared with steroidal androgens. |
Journal of Bone & Mineral Research |
Research Status:
Androgen Receptor Selectivity:
LGD-3033 is designed to selectively bind to androgen receptors in muscle and bone tissues. The goal is to stimulate anabolic (muscle-building) processes without significantly affecting other tissues that are commonly impacted by anabolic steroids (such as the prostate).
Potential Effects:
Based on its design as a SARM, LGD-3033 might offer:
Lack of Standardized Protocol:
Due to the experimental nature of LGD-3033, there is no medically or scientifically validated dosage. Most dosing guidelines circulating online are based on anecdotal reports and user experiences rather than rigorous clinical research.
Cycle Recommendations:
In anecdotal discussions within underground forums, some users report cycles ranging from 6 to 8 weeks. However, these are not clinically approved regimens and come with risks.
Stacking Practices:
Some individuals may stack LGD-3033 with other SARMs or compounds. Such combinations can increase the complexity of the effects and the potential for adverse reactions.
Side Effects:
While SARMs are often touted for their reduced side effect profile compared to anabolic steroids, potential risks still exist:
Post-Cycle Therapy (PCT):
Anecdotal evidence suggests that some users might employ a PCT regimen after a cycle to help restore natural hormone levels. However, without clinical guidance, this practice can be risky.
Research Chemical:
LGD-3033 is typically sold as a research chemical. It is not approved by regulatory agencies (such as the FDA or EMA) for human consumption or as a dietary supplement.
Legality:
The legal status of SARMs, including LGD-3033, varies by country. In many regions, possession or sale for human use can be illegal, and products are intended strictly for laboratory research purposes.
Need for Clinical Trials:
More rigorous, controlled human studies are needed to determine the efficacy, safety, and proper dosing of LGD-3033.
Potential Medical Applications:
If proven safe, SARMs like LGD-3033 could have therapeutic potential in treating muscle-wasting diseases, osteoporosis, and other conditions where muscle and bone health is compromised.