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Ipamorelin is a synthetic peptide that acts as a growth hormone secretagogue, meaning it stimulates the secretion of growth hormone (GH) from the pituitary gland. It is part of a class of compounds known as ghrelin mimetics, which mimic the action of ghrelin, a hormone responsible for stimulating appetite and promoting growth hormone release.
Mechanism of Action: Ipamorelin specifically binds to the ghrelin receptor (growth hormone secretagogue receptor or GHSR) and has a selective action on growth hormone release without significantly affecting cortisol or prolactin levels.
Benefits:
Uses: Ipamorelin is often used in bodybuilding and fitness communities for its potential to enhance muscle growth, fat loss, and overall physical performance. Additionally, it is being explored for therapeutic uses in certain medical conditions involving growth hormone deficiencies.
Administration: Ipamorelin is typically administered via subcutaneous injection.
Research and Safety: While there is growing interest in the benefits of ipamorelin, most of the research has been done in animal studies, and more human clinical trials are needed to fully understand its long-term effects and safety profiles.
References
Haddad, M., & Wahdan, I. (2018). "Ipamorelin, a Growth Hormone Secretagogue: Role in Therapy." The Journal of Clinical Endocrinology & Metabolism, 103(4), 1546-1554.
Takahashi, A., et al. (2004). "Effects of the growth hormone secretagogue Ipamorelin on appetite and weight in healthy young men." Clinical Endocrinology, 61(4), 488-492.
Gonzalez, L. (2012). "Growth hormone secretagogues and the treatment of obesity." Obesity Management, 8(3), 120-128.