NOT FOR HUMAN CONSUMPTION

Kisspeptin-10 is a short peptide fragment derived from the larger kisspeptin family, which plays a crucial role in regulating the reproductive system. It is a potent activator of the hypothalamic-pituitary-gonadal (HPG) axis, stimulating the release of gonadotropin-releasing hormone (GnRH), which in turn regulates luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion.

Mechanism of Action

Kisspeptin-10 binds to the KISS1 receptor (GPR54) in the hypothalamus, leading to:

1. Increased GnRH secretion → Stimulates the anterior pituitary.
2. Release of LH & FSH → Essential for testosterone and estrogen production.
3. Enhanced fertility & puberty regulation → Critical in the onset of puberty and reproductive function.

Unlike synthetic hormones or exogenous testosterone, Kisspeptin-10 enhances natural hormone production without suppressing endogenous feedback mechanisms.

Uses and Potential Benefits

1. Fertility & Reproductive Health

   • Stimulates ovulation in women.
   • Increases sperm production and testosterone in men.
   • Potential treatment for hypogonadotropic hypogonadism (low GnRH/LH levels).

2. Libido and Sexual Function

   • Enhances sexual desire and arousal.
   • Works synergistically with other peptides like PT-141 (Bremelanotide).

3. Puberty Regulation

   • Used in research for delayed or precocious (early) puberty.
   • Helps restore natural puberty in KISS1/GPR54 deficiency disorders.

4. Neuroprotective & Metabolic Effects

   • May influence energy balance and appetite regulation.
   • Shows promise in preventing neurodegenerative diseases like Alzheimer’s.

5. Potential Anti-Cancer Properties

   • Originally discovered as a metastasis suppressor gene (KISS1), inhibiting tumor spread in certain cancers.

Dosage & Administration

• Common Route: Subcutaneous injection.
• Typical Dosage: Research suggests 50–100 mcg per injection, but human studies are limited.
• Timing: Often administered pre-bedtime or pre-sexual activity for libido effects.

Side Effects & Risks

• Mild Side Effects: Nausea, dizziness, temporary flushing.
• Potential Hormonal Imbalances: Overuse could lead to excessive LH/FSH production.
• Unknown Long-Term Effects: More clinical trials are needed

  
  

  
  

  
  

  Clinical Research & Legality

  • Currently under research for fertility treatments and neuroendocrine disorders.
  • Not FDA-approved for general medical use but available in research settings.

  
  

References

• Oakley, A. E., Clifton, D. K., & Steiner, R. A. (2009). Kisspeptin signaling in the brain. Endocrine Reviews, 30(6), 713-743.

• Dhillo, W. S., Chaudhri, O. B., Patterson, M., Thompson, E. L., Murphy, K. G., Badman, M. K., ... & Bloom, S. R. (2005). Kisspeptin-54 stimulates the hypothalamic-pituitary-gonadal axis in human males. Journal of Clinical Endocrinology & Metabolism, 90(12), 6609-6615.

• Jayasena, C. N., Comninos, A. N., & Dhillo, W. S. (2014). Kisspeptins and the control of gonadotropin secretion in humans. Peptides, 56, 34-40.

• George, J. T., Anderson, R. A., Millar, R. P., & Tena-Sempere, M. (2012). Kisspeptin-10 is a potent stimulator of the hypothalamic-pituitary-gonadal axis in women. Journal of Clinical Endocrinology & Metabolism, 97(10), 3629-3636.