NOT FOR HUMAN CONSUMPTION

MK-777 (Acetamoren)  is sold online as a research-only small-molecule ghrelin/secretagogue receptor (GHSR-1a) agonist and analog of MK-677 (ibutamoren). It is not an approved medicine and there are no peer-reviewed human or animal studies publicly indexed as of now. Chemical directories and vendors list CAS 950841-87-9 with an indole–piperidine “spiro” scaffold and the following identifiers: IUPAC (propanamide, 2-(acetylamino)…), MF ≈ C29H38N4O6S, MW ≈ 570.7 g/mol. Claims that MK-777 is “more selective/potent” than MK-677 are marketing assertions, not independent data.

Additional Benefits Now Being Marketed/Proposed (evidence caveats)

2. Chemical/Mechanistic Notes

• Listed identifiers (vendor/registry sites):

  • CAS: 950841-87-9; names “Acetamoren”, “MK-777”.

  • IUPAC (as listed): Propanamide, 2-(acetylamino)-N-[(1R)-2-[1,2-dihydro-1-(methylsulfonyl)spiro[3H-indole-3,4′-piperidin]-1′-yl]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]-2-methyl-(ACI).

  • Formula/MW: C29H38N4O6S, ~570.7 g/mol.

  • (Note: several vendor pages show slightly different formulas/weights—another sign that the identity record isn’t harmonized.) ChemicalBook+1

• Purported class: Non-peptide GHSR-1a agonist (ghrelin mimetic), often mis-tagged online as a “SARM,” which it is not. 

Inference from class (if it truly activates GHSR-1a): Expect GH pulses → ↑IGF-1/IGFBP-3, orexigenic signaling (hunger), possible water/sodium retention, and class-typical glucose/insulin effects—but the dose–response, half-life, and off-targets for MK-777 are unknown.

3. Pharmacokinetics / Dosing

• No peer-reviewed PK exists for MK-777. Any reported half-life or oral bioavailability on vendor pages should be considered unverified marketing. Compare with MK-677 only as background class context, not as evidence for MK-777.

4. Safety & Tolerability (risk framing)

Without clinical data, safety must be inferred from ghrelin-agonist class (e.g., MK-677):

• Likely on-target effects: Increased appetite, transient hunger, peripheral edema, hand/foot stiffness/paresthesias, weight gain (water/FFM); vivid dreams for some.

• Metabolic: Potential worsening of fasting glucose/insulin resistance in susceptible people; lipid shifts possible.

• Endocrine: Class can nudge cortisol/prolactin in some reports with analogs; MK-777-specific data unknown.

• Cardio-renal: Sodium/water retention → BP drift in sensitive individuals.

• Drug testing: Ghrelin mimetics used for GH stimulation are prohibited by WADA; many labs screen for GH axis manipulation.

• Unknowns: Carcinogenicity, reproductive toxicity, genotoxicity, long-term hepatic/renal effects—no datasets available for MK-777.

Practical harm-reduction: If anyone is handling this in a lab, verify identity/purity by independent NMR/LC-MS, maintain chain-of-custody, and avoid human exposure. “For research only” vendors explicitly state not for human consumption. Kimera Chems

5. Regulatory & Sourcing Reality

• MK-777/“Acetamoren” appears only on vendor/marketplace and chemical-trader listings(Amazon/eBay/Alibaba/chem directories); it is absent from major curated drug/chemical knowledge bases with peer-reviewed data (e.g., no public PubChem compound page tied to this CAS at time of checking). Treat the CAS/structure as provisional. ChemicalBook+2eBay+2

• Sellers label it “research chemical, not for human use.” Kimera Chems

6. How it compares (based on class, not head-to-head trials)

7. Bottom line (clear & cautious)

• CAS 950841-87-9 corresponds online to “Acetamoren/MK-777,” a marketed analog of MK-677 with no independent literature confirming pharmacology, efficacy, PK, or safety. Chemical identifiers posted by sellers/registries may not be harmonized. ChemicalBook

• If you’re evaluating it scientifically, treat it like any novel, unvalidated small molecule: confirm identity, purity, and stability yourself, and do not use in humans. Vendor claims about superiority to MK-677 are unsubstantiatedat this time.